GENOME ANNOTATION AND FUNCTIONAL GENOMICS The protein sequence perspective. - ppt download

GENOME ANNOTATION AND FUNCTIONAL GENOMICS The protein sequence perspective. - ppt download: WHY PROTEIN RATHER THAN DNA? Larger alphabet -more sensitive comparisons Protein sequences lower signal to noise ratio Less redundancy and no frameshifts Each aa has different properties like size, charge etc Closer to biological function 3D structure of similar proteins may be known Evolutionary relationships more evident Availability of good, well annotated protein sequence and pattern databases